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Stefano Bonassi
Head, Clinical and Molecular
Epidemiology, IRCCS San Raffaele Pisana, Roma
Drug
safety and efficacy in elderly affected by non communicable
diseases. Tools and opportunities to improve the quality of care
The control of Non
Communicable Diseases (NCDs) is among the most serious global
health problems of the twenty-first century, causing severe
morbidity and high mortality all over the world, while setting
intolerable management needs in terms of healthcare systems
sustainability. NCDs are impeding healthy ageing, thereby having
wide impact on quality of life people around the word.
NCDs result from the interaction of genetic and environmental
factors and cluster in a not yet completely understood way,
making the identification of the resulting summative phenotypes
a top priority to be addressed. The degree of complexity
required to interpret large datasets generated by advanced
high-throughput functional genomics assays is increased to the
point that novel computational biology approaches are needed to
extract information relevant to the clinical decision making
process. Systems-level models interpreting the interaction
between extensive cellular and molecular measurements and
clinical features are created to identify new disease phenotypes
to optimize disease definition and treatment. Likewise, systems
medicine platforms with extensively characterized patients
provide a basis for more targeted clinical trials, and represent
a promising tool to achieve better prevention and patient care,
thereby promoting global healthy ageing. The presentation will
reviews the novel systems approaches to NCD and its potential
effect on drug safety and efficacy in elderly. The scientific
and clinical background of the San Raffaele Systems Medicine
Platform will be discussed together with the advantages and
perspectives of multi-disease clinical platforms.
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